Yang, J., Yamamoto, T., Gopalan, S., Cui, G., Diehn, M., Berger, J., Loo, B. W., Graves, E. E., Keall, P. J. Rothenberg, M. E., Clarke, M. F., Diehn, M. STEREOTACTIC ABLATIVE RADIOTHERAPY SHOULD BE COMBINED WITH A HYPOXIC CELL RADIOSENSITIZER. Noninvasive pulmonary nodule elastometry by CT and deformable image registration. First, the presynaptic response to an ionophore-mediated Ca(2+) elevation was 50% greater, indicating an enhanced Ca(2+) sensitivity of the release machinery. Consensus guidelines from the NCCN recommend performing INE for patients with T2N0 tumors and considering INE for those with T1N0 tumors. In this work, we aimed to identify an imaging signature for predicting progression-free survival (PFS) of locally advanced NSCLC. Bratman, S. V., Diehn, M., Rajasekhar, V. K. Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation. The site facilitates research and collaboration in academic endeavors. A. Pre-treatment circulating tumor DNA as a biomarker for disease burden in diffuse large B cell lymphoma (DLBCL). Schaner, M. E., Ross, D. T., Ciaravino, G., Sorlie, T., Troyanskaya, O., Diehn, M., Wang, Y. C., Duran, G. E., Sikic, T. L., Caldeira, S., Skomedal, H., Tu, I. P., Hernandez-Boussard, T., Johnson, S. W., O'Dwyer, P. J., Fero, M. J., Kristensen, G. B., Borresen-Dale, A. L., Hastie, T., Tibshirani, R., van de Rijn, M., Teng, N. N., Longacre, T. A., Botstein, D., Brown, P. O., Sikic, B. I. Individuality and variation in gene expression patterns in human blood. A CT visible pathway was delineated for EM guided placement of an HDR applicator (catheter) and dwell times were optimized to ensure at least 98% prescription dose coverage of the GTV. Circulating tumor DNA (ctDNA) shed from cancer cells into the peripheral blood can be non-invasively collected and tested for the presence of tumor-specific mutations. We densely characterized early ctDNA dynamics during therapy using cancer personalized profiling by deep sequencing to define response-associated thresholds within a discovery set. View details for Web of Science ID 000353645800019. standard care in preventing pain. The induced genes whose expression was most enhanced by costimulation were significantly enriched for known targets of nuclear factor of activated T cells (NFAT) transcription factors. It is not yet known Integrating these determinants, we developed and validated an entirely noninvasive multiparameter assay (DIREct-On, Durable Immunotherapy Response Estimation by immune profiling and ctDNA-On-treatment) that robustly predicts which patients will achieve DCB with higher accuracy than any individual feature. For example, V4DCT(HU) defect volume increased significantly with decreasing FEV1/FVC (R=-0.65, P Both her age and mean dose to her SAN were the third highest in our cohort. provides an active community for patients and survivors—and those water-soluble iodinated compounds as the contrast agents. types of cancer therapies. A., Diehn, M. Predicting Radiotherapy Responses and Treatment Outcomes Through Analysis of Circulating Tumor DNA. Hong, J. C., Yu, Y., Rao, A. K., Ditererich, S., Maxim, P. G., Le, Q., Diehn, M., Sze, D. Y., Kothary, N., Loo, B. W. MID-RADIATION THERAPY PET CORRELATES WITH SURVIVAL IN LOCALLY ADVANCED NSCLC. Non-small-cell lung cancer (NSCLC) represents approximately 80-85% of lung cancer diagnoses and is the leading cause of cancer-related death worldwide. Newer potential indications for SABR include treatment of operable patients; of oligometastatic lung cancer, in which SABR has emerged as an alternative to metastasectomy; and of oligoprogressive lung cancer, an attractive concept especially as improved personalized systemic therapies emerge, and prospective trials are currently being conducted in these settings. SBRT is now an accepted View details for Web of Science ID 000444944200019. We evaluated the outcomes and imaging prognostic factors of HypoRT.We retrospectively reviewed the data from all patients with primary and metastatic intrathoracic tumors treated with HypoRT from 2006 to 2012. The most common co-mutation in both the KEAP1/NFE2L2/CUL3 mutant and wild-type cohort was TP53. A., Popat, R., Maxim, P. G., Guo, H. H., Diehn, M., Nair, V. S., Loo, B. W. Intratumor Partitioning of Serial Computed Tomography and FDG Positron Emission Tomography Images Identifies High-Risk Tumor Subregions and Predicts Patterns of Failure in Non-Small Cell Lung Cancer After Radiation Therapy. research program, oversees the Foundation's translational research Although the molecular actions of thyroid hormones have been studied thoroughly, their pleiotropic effects are mediated by complex changes in expression of an unknown number of target genes. It is currently understood that hypoxic tumors are more A., Loo, B. W., Diehn, M. Circulating tumor DNA dynamics predict benefit from consolidation immunotherapy in locally advanced non-small-cell lung cancer. strategy and ensures that grants are awarded to researchers whose B., Ross, J. works in preventing esophagitis-related pain in patients receiving chemotherapy and radiation Feng, W., Gentles, A., Nair, R. V., Huang, M., Lin, Y., Lee, C. Y., Cai, S., Scheeren, F. A., Kuo, A. H., Diehn, M. Imaging features associated with disease progression after stereotactic ablative radiotherapy for stage I non-small-cell lung cancer. A total of 60 patients were eligible: 19 patients (86%) who received CRT and 29 (76%) who received CRT plus panitumumab and underwent an operation. To verify the geometric accuracy of gated RapidArc treatment using kV images acquired during dose delivery.Twenty patients were treated using the gated RapidArc technique with a Varian TrueBeam STx linear accelerator. For more information, please contact Justin Carter, 650-725-4796. Breath Analysis for Evaluation of Radiation Exposure in Lung Cancer Patients Treated With Radiation. Separately, we identified 51 stage IV NSCLC patients with KEAP1, NFE2L2, or CUL3mutations and a matched cohort of 52 wildtype patients. Nine patients also had baseline plasma samples available, and all had detectable ctDNA prior to therapy initiation. Binkley, M. S., Shrager, J. Differentiating local recurrence from post-treatment changes on PET scans following stereotactic ablative radiotherapy (SABR) or hyperfractionation for lung tumors is challenging. However, the reduction should not come at the cost of too much information, allowing for sensible statistical analysis after its application. Stem cell-based regenerative therapy is a promising treatment for head and neck cancer patients that suffer from chronic dry mouth (xerostomia) due to salivary gland injury from radiation therapy. Although previous studies have suggested that treating multiple lung tumors with SABR is safe, post-treatment changes in respiratory function have not been analyzed in detail.We retrospectively identified patients with 2 or more primary lung cancers or lung metastases treated with SABR and analyzed clinical outcomes and predictors of toxicity. Sorted cells were then injected into recipient background FVB/NJ female syngeneic mice. Patients treated with radiation therapy for lung tumors can experience inflammation after Giving lapatinib Deletion of Trp53 and Keap1 in ABSCs, but not more differentiated tracheal cells, produced tumors recapitulating histologic and molecular features of human LSCCs, indicating that they represent the likely cell of origin in this model. Additionally we present a classification model following a "Bag of Covariance Descriptors" paradigm in order to distinguish three different nodule tissue types in CT: solid, ground-glass opacity, and healthy lung. into or near a tumor to kill tumor cells. Diehn, M., Bhattacharya, R., Botstein, D., Brown, P. O. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Time to toxicity was defined from start of SABR.Of 47 patients with central tumors in the right lung treated with SABR reviewed, 13 met our study criteria. In NSCLC patients, median time to treatment failure (TTF) after first line chemotherapy for the KEAP1/NFE2L2/CUL3-mutant cohort was 2.8 months compared to 8.3 months in the control group (p < 0.0001) Median overall survival (OS) was 11.2 months in the KEAP1/NFE2L2/CUL3-mutant group and 36.8 months in the control group (p = 0.006). and improving lives for lung cancer survivors. Deep sequencing of circulating tumor DNA for personalized cancer detection and monitoring, Regional Failure After Stereotactic Ablative Radiation Therapy for Early-Stage Lung Cancer. View details for DOI 10.1016/j.ijrobp.2015.12.007, View details for DOI 10.1016/j.cllc.2015.12.001, View details for DOI 10.1158/1538-7445.SABCS15-ES5-2, View details for Web of Science ID 000375622400176, View details for Web of Science ID 000427344900003, View details for DOI 10.1145/2975167.2985663, View details for Web of Science ID 000433385100077, View details for Web of Science ID 000368019000178, View details for Web of Science ID 000368019000194, View details for DOI 10.1158/1538-7445.TRANSCAGEN-PR09, View details for Web of Science ID 000370972600122. cancers (colorectal, breast, and prostate) combined, Only 21% of all people diagnosed with lung cancer will survive Newman, A. M., Steen, C. B., Liu, C., Gentles, A. J., Chaudhuri, A. Radiotherapy can result in lymphopenia, which has been linked to poorer survival. Half of LRs occurred in KEAP1/NFE2L2 mutation tumors, indicating they are major molecular drivers of clinical radioresistance. Scientific Advisory Board. block the ability of tumor cells to grow and spread. Supervised analyses identified gene expression signatures for B-cells (427 genes), T-cells (222 genes), CD8+ T-cells (23 genes), granulocytes (411 genes), and lymphocytes (67 genes). We determined cumulative dose to critical structures, rates of toxicity, and outcomes following thoracic reirradiation.We retrospectively reviewed our institutional database for patients treated between 2008 and 2014, who received thoracic reirradiation with overlap of 25% prescribed isodose lines. Here we describe a basal signal that controls gene expression profiles in the Jurkat T cell line and mouse thymocytes. View details for DOI 10.1016/j.lungcan.2012.08.016, View details for Web of Science ID 000311881400008, View details for DOI 10.1016/j.ijrobp.2012.07.1523, View details for Web of Science ID 000310542901651, View details for DOI 10.1016/j.ijrobp.2012.07.1621, View details for Web of Science ID 000310542902036. Among the best discriminators more highly expressed in the ovarian carcinomas were PAX8 (paired box gene 8), mesothelin, and ephrin-B1 (EFNB1). Stereotactic ablative radiotherapy (SABR) is highly effective at controlling early stage primary lung cancer and lung metastases. Markers remaining near the tumor were scored as retained. Activity of the HIF1alpha pathway is correlated with patient survival in all the subtypes evaluated.Conclusion: These findings clarify the relevance of the UPR pathways in different breast cancer subtypes and underscore the potential therapeutic importance of the IRE1alpha-XBP1 branch in breast cancer treatment. To determine the clinical impact of calculated dose differences between effective path length (EPL) and Monte Carlo (MC) algorithms in stereotactic ablative radiation therapy (SABR) of lung tumors.We retrospectively analyzed the treatment plans and clinical outcomes of 77 consecutive patients treated with SABR for 82 lung tumors between 2003 and 2009 at our institution. Gensheimer, M. F., Hong, J. C., Chang-Halpenny, C., Zhu, H., Eclov, N. W., To, J., Murphy, J. D., Wakelee, H. A., Neal, J. W., Le, Q., Hara, W. Y., Quon, A., Maxim, P. G., Graves, E. E., Olson, M. R., Diehn, M., Loo, B. W. Practical workflow for rapid prototyping of radiation therapy positioning devices. View details for DOI 10.1148/radiol.11101688, View details for Web of Science ID 000295039000006. View details for DOI 10.1634/stemcells.2007-0440, View details for Web of Science ID 000253372600008. There was no grade ≥3 toxicity. View details for DOI 10.1186/1471-2164-7-115, View details for Web of Science ID 000238364000001, View details for PubMedCentralID PMC1479811.

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